Anti-cell adhesion characteristics of nanotextured surface for implantable biomedical device

Abstract

In this study, anti-cell adhesion characteristics of a nanotextured polymer surface prepared by a nano-imprint process were investigated by culturing NIH 3T3 fibroblast cells on the surface. The nanotextured surface, made of biocompatible polymer, was covered by nanodimples having a diameter of 220± 5 nm and inter-hole distance of 320 ± 5 nm. Migration of NIH 3T3 cells was confined within a small area, and cell aggregation was observed on the nanotextured surface. Aggregated cells were fully viable. On the other hand, NIH 3T3 cells cultured on a smooth surface actively migrated and eventually covered the entire surface area after 56 hours. Because the nanotextured surface displayed anti-cell adhesion characteristics without causing apoptosis, it can be used in implantable biomedical devices to confer anti-cell adhesion properties without any chemical treatment.