Abstract
Leaf extract of 12 medicinal plants were obtained by using 10mM sodium phosphate buffer and studied for their antibacterial activity against 6 cariogenic pathogens. Among them, the extract from Streblus asper showed the most intensive activity. Antibacterial activity of Streblus asper was investigated by the minimum inhibitory concentration (MIC) test and the viable cell count method. MIC of Streblus asper against Candida albicans causing dental caries was determined to be 2.5 μg/ml. The kinetic study showed that Streblus asper completely inactivated C. albicans at the concentration 50μg/ml in 15hours.Hemolytic study of the Streblus asper plant leaf protein gives HC50 value at a very high range than that of the MIC values against C. albicans of the organisms and thus flourish its application as successful pharmaceutical drug in practice. DOI: http://dx.doi.org/10.3126/ijasbt.v2i3.9344Int J Appl Sci Biotechnol, Vol. 2(3): 253-259
Highlights
The human oral cavity is a habitat for about 500 cultivable and non-cultivable bacterial species (Paster et al, 2001) Dental caries is a transmissible infectious disease (Tanzer, 1995)
The oral yeast tends to increase as a result of an increment in the number of retentive sites such as prostheses, orthodontic appliances and pacifiers (Ollila et al, 1997) other factors such as the socioeconomic conditions seem to interfere in the colonization by Candida (Coulter et al, 1993, Russel et al, 1990)
Maximum activity was against Streblus asper (36mm). and minimum activity against Mimusops elengi (19mm) Inhibitory effect of Streblus asper is same as of antibiotics .Out of all the 12 plant leaf protein extracts, except Ficus racemosa leaf protein extract- (17mm) no other plant has shown activity against Lactobacillus acidophilus
Summary
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