Abstract
The aims of this study are to determine anticardiolipin antibodies in patients with Sy Behcet and to determine correlation between the levels of anticardiolipin antibodies in serum in patients with clinic systemic and ocular manifestations. The study was conducted on 11 patients with Behcet disease (group I), and on 11 healthy subjects (group II). Anticardiolipin antibodies -aCL were determined by the standard ELISA method, where 1GPL= 1 microgram/ml IgG aCL and 1 MPL= 1 microgram/ ml IgM, and were considered negative < 10 GPL or MPL, low positive (10-40 GPL and MPL), or high positive (>40 GPL and MPL). In the group of 11 patients with the diagnosis Sy Behcet, 6 of them were (54.5%) with values of anticardiolipin antibodies over 10 positive. In the control group of the healthy examinees aCl were positive in 2 cases (18.2%). There are no statistically significant differences in the presence of systemic clinic characteristics between aCl positive and negative patients. All the patients with SY Behcet in whom anticardiolipn antibodies were found have extremely severe visual damage which is not present in the group of those patients where the values of aCl were low. The difference is statistically significant. The level of anticardiolipin antibodies is increased in the patients with Behcet. There are no statistically significant differences in the presence of systemic clinical characteristics between aCL positive and negative patients. Visual acuity in patients with SY Behcet is statistically significantly much lower in patients who had increased values of aCL.
Highlights
Behcet’s disease is a multi - system disease named after the Turkish dermatologist Dr Hulusi Behcet ( - ), who described the triad of symptoms in, such as eye inflammation, oral and genital ulcers [, ]
It was thought that the basic mechanism leading to histological changes was immune complex deposition, because deposition of complement components was proved in some lesions [, ]
We only found the statistical significance in correlation of visual acuity and presence of anticardiolipin antibodies
Summary
Behcet’s disease is a multi - system disease named after the Turkish dermatologist Dr Hulusi Behcet ( - ), who described the triad of symptoms in , such as eye inflammation, oral and genital ulcers [ , ] The diagnosis of this disease is mostly based on clinical findings. Thrombocytopenia and frequent vasculitis are common manifestations of Behcet’s disease, there is a need to search for anticardiolipin antibodies in serum in these patients [ , ]. They paid special attention to the connection between clinical manifestations and titra anticardiolipin antibodies in serum [ , , ]. The aims of the study were to determine the presence of anticardiolipin antibodies in patients with Sy Behcet and to determine the correlation between the level of anticardiolipin antibodies in serum of the patients and retinal vascular complications
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
