Anticandidosis activity of aqueous and ethanolic extracts of Harungana madagascariensis, Zanthoxylum leprieurii and Xylopia aethiopica

Abstract

Some ailments have been cured either by the use of plant parts or by mixing different plant parts (recipes). It is with this in mind that this study originated, focusing on the valorization of plants from the African pharmacopoeia. Thus, the activity of single extracts and aqueous and hydroalcoholic mixtures of the bark and leaves of Harungana madagascariensis, the bark of Zanthoxylum leprieurii and the fruit of Xylopia aethiopica was evaluated on the in vitro growth of Candida strains (Candida albicans 18650 and Candida albicans 18792 and Candida glabrata). Antifungal tests were carried out by plating 1,000 cells of each fungal germ on Sabouraud agar medium using the double dilution slant tube method. Deth70% extract inhibited the growth of Candida albicans 18650 and Candida albicans 18792 at an FMC value of 25 mg/mL, and Candida glabrata at an FMC value of 50 mg/mL. Phytochemical screening revealed the presence of chemical compounds such as polyphenols, flavonoids, saponosides, gallic and catechic tannins and the absence of sterols.