Anti-candidal activity of Aspergillus flavus IBRL-C8, an endophytic fungus isolated from Cassia siamea Lamk leaf

doi:10.7324/japs.2018.8213

Abstract

Gallic acid: An anticandidal compound in hydrolysable tannin extracted from the barks of Rhizophora apiculata BlumeLim Sheh Hong, Darah Ibrahim, Jain Kassim, Suraya Sulaiman

Highlights

There has been an alarming increase in life threatening systemic fungal and yeast infections of varying types which are observed in immunosuppressed and immunocompromised person such as AIDS, cancer, and transplant patients
The time-kill curve study was performed at three different extract concentrations (1/2MIC, minimal inhibitory concentration (MIC) and 2MIC) and the results showed that the C. albicans cell growth was concentration dependent
The results demonstrated that the ethyl acetate extract which contained the compounds secreted extracellularly into the fermentation medium by the fungus exhibited significant anti-candidal activity with 28.3 ± 2.4 mm of inhibition zone

Summary

Introduction

There has been an alarming increase in life threatening systemic fungal and yeast infections of varying types which are observed in immunosuppressed and immunocompromised person such as AIDS, cancer, and transplant patients. Yeasts especially the Candida albicans has emerged as significant pathogens in recent decades as a consequence of increasing numbers and population of immunocompromised patients (Fostel and Latey, 2000; Kim and Sudbery, 2011). As a result, they have become a main cause of death in patients who treated for malignant diseases and emerging immune deficiency diseases (Xiang et al, 2013). As a result of the increasing prevalence of resistant fungal and yeast strains, Levy (2005) has reported endophytes are a new finding for potentially useful medicinal compounds to overcome the drug resistance issue. Endophyes able to produce some pharmacologically compounds and which having diverse structural groups and showing antimicrobial activity, anticancer, antioxidant, insecticide, and etc (Demain, 1999; Tan and Zou, 2001; Liang et al 2012; Idris et al 2013; Gherbawy and Gashgari, 2014; Bhardwaj et al 2015)

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Conclusion