Abstract
Background/aimLactic acid bacteria prevent the overgrowth of pathogenic agents and opportunistic pathogens in the vagina. Moreover, lactic acid bacteria contribute to the preservation of vaginal microbiota by producing antimicrobial agents. Previous studies showed that some lactic acid bacteria exhibited antimicrobial activity against Candida species causing yeast vaginosis as well as many bacterial pathogens.Materials and methods The antifungal activities of various lactic acid bacteria isolated from the vagina of healthy women on some Candida species isolated from the vagina were investigated by agar diffusion technique. Results Most of the lactic acid bacteria that belong to the species of Lactobacillus crispatus, L. fermentum, L. acidophilus, L. paracesei subsp. paracesei, L. pentosus, and L. plantarum exhibited antifungal activity in varying ratios against C. albicans, C. glabrata, and C. tropicalis strains isolated from the vagina.Conclusion The lactic acid bacteria are useful microorganisms associated with a variety of probiotic properties. In this sense, our lactic acid bacteria isolates with high antifungal activity may be promising candidates as probiotic microorganisms in the inhibition of vaginal candidiasis, which is one of the most prevalent problems, or in the protection against candidiasis. We will continue our studies in this area.
Highlights
Human microbiota colonized in human body consists of trillions of microorganisms
Most of the lactic acid bacteria that belong to the species of Lactobacillus crispatus, L. fermentum, L. acidophilus, L. paracesei subsp. paracesei, L. pentosus, and L. plantarum exhibited antifungal activity in varying ratios against C. albicans, C. glabrata, and C. tropicalis strains isolated from the vagina
The lactic acid bacteria are useful microorganisms associated with a variety of probiotic properties
Summary
Human microbiota colonized in human body consists of trillions of microorganisms. Different microbial communities were located in the vagina, mouth, skin, gastrointestinal tract, nose, urethra, and other parts of the body [1].Lactobacillus species are dominant in the vaginal microbiota of healthy women [2]. Human microbiota colonized in human body consists of trillions of microorganisms. Different microbial communities were located in the vagina, mouth, skin, gastrointestinal tract, nose, urethra, and other parts of the body [1]. Lactobacillus species are dominant in the vaginal microbiota of healthy women [2]. Premenopausal healthy women have 107–108 colony forming unit/gram lactobacilli in their vaginal fluid [3]. The lactobacilli in the vaginal microbiota protect the flora against the colonization of other sexually transmitted infectious agents such as bacterial vaginosis, urinary tract infections, vulvovaginal candidiasis, and AIDS. It was suggested that this is carried out through adhesion to the Vulvovaginal candidiasis is a common infection seen in women throughout their lives. Drutz reported that oral administration of Lactobacillus acidophilus has a protective effect against Candida vaginitis [7]
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