Abstract
Cancer is a major cause of death worldwide, as exemplified by millions of cancer diagnoses every year. The use of chemotherapy in treating cancer has many disadvantages which include recurrence of cancer, associated with drug resistance, and severe side effects that are harmful to the patients. A better source of anticancer drugs can come from nature. Strobilanthes crispus (S. crispus) is a herbal medicinal plant that is indigenous in Madagascar and the Malay Archipelago. The plant possesses high vitamin and mineral content as well as phytochemicals—like phenols, catechins, tannins, and flavonoids—that are known to have therapeutic effects. Numerous preclinical studies have reported very versatile pharmacological effects of this plant, such as anticancer, antimicrobial, antioxidant, anti-angiogenesis, anti-diabetes, anti-ulcerogenic, and wound healing. Herein, this paper reviews the anticancer properties of S. crispus, providing information for future research and further exploration.
Highlights
Cancer refers to uncontrolled cellular growth which is mainly caused by genetic and environmental factors [1]
Since MCF-7 and MDA-MB-231 are estrogen receptor (ER)-dependent and ER-independent cell lines, respectively, the results suggested that the tumoricidal effects of stem chloroform (SC)/D-F9 is independent of the expression of estrogen receptor on the cells
The results revealed that in MCF-7 cells, S. crispus (SCS) induced an increase in cyclin D1, p21 and p53 proteins, and a decrease in cyclin E after 24-h treatment while it did not induce any significant change in level of cyclins A and B
Summary
Cancer refers to uncontrolled cellular growth which is mainly caused by genetic and environmental factors [1]. The tea tastes slightly bitter due to the high content of cystoliths of calcium carbonate and the alkaline infusion gotten from this plant [37,38,41] They customarily ingest this plant as a remedy for various diseases or medical conditions—such as diabetes, calculi (kidney stones), hypertension, and constipation—as well as to enhance immunity in order to prevent the development of cancer [37,41,42]. Most importantly, according to a number of studies carried out, the results showed that this plant exhibited anti-cancer features This is significant since cancer is still a tremendous burden and it has caused millions of death worldwide.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
