Abstract
Cancer is an advanced disease characterized by numerous etiologies and multiple stages evoked by the deregulation in genetic and epigenetic programs via many factors like hormonal perturbation, microbial infections and chemical carcinogenesis. Once cells become cancerous, they still divide forever with none response of sign programmed cell death or senescence. Treatment relies on radiotherapy and chemotherapy that target cells with fast division. These treatments cause numerous side effects on normal cells division. Natural products have continually and historically been studied for promising new leads in pharmaceutical development. Several plant parts are utilized in traditional medicine because they are easily available in rural areas and less expensive compared to new synthetic therapeutic drug. Moringa peregrina (M. peregrina), which belongs to the monogenic Moringaceae family, offers these advantages. Moringa trees possess different medicinal and nutritional value. This current review focuses on the chemical and biological properties of M. peregrina as a promising source of anti-cancer agent(s).
Highlights
Cancer is a cluster of diseases involving abnormal cell growth with the potential to spread to extra parts of the body (Anand et al, 2008)
Apoptosis is a form of programmed cell death, the mechanism by which cells are programmed to die within the event they become damaged
The apoptosome is formed when cytochrome c is released into the cytoplasm and binds to Apoptotic Protein Activating Factor 1 (APAF-1)
Summary
Cancer is a cluster of diseases involving abnormal cell growth with the potential to spread to extra parts of the body (Anand et al, 2008). A neoplasm or tumor is a cluster of cells that have undergone unregulated growth, and will regularly produce a mass or lump, may be spread diffusely (Kravchenko et al, 2009). Not all tumors are cancerous; benign tumors do not invade other parts of the body (Pan et al, 2019). Cancer is amongst the major noncommunicable diseases causing death worldwide. Cancer alone accounts for 21.7% of all noncommunicable diseases (Tiloke et al, 2016)
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