Abstract
Cancer is one of the most major diseases that threatens human health and life. The aim of this work was to obtain novel anticancer molecules from D. fragrans, a kind of medicinal plant. The structure of the new compound was identified using spectroscopic data (1H-NMR, 13C-NMR and two dimensions NMR). Its anticancer properties were evaluated using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay against four human cells including lung cancer cells (A549), breast cancer cells (MCF-7), gastric cancer cells (SGC7901) and noncancerous human umbilical vein endothelial cells (HUVEC). A new phenylpropanoid—(E)-caffeic acid-9-O-β-d-xylpyranosyl-(1→2)-β-d-glucopyranosyl ester (1), with seven known compounds (2–8)—was isolated. The IC50 value of compound 1 against MCF-7 cells was 2.65 ± 0.14 µM, and the IC50 values of compound 8 against three cancer cells were below 20 µM.
Highlights
D. fragrans (Figure 1), from the Dryopteris genus of the Dryopteris family, is a deciduous perennial herb that is mostly distributed in Northeast China, Korea Japan, Russia and North America. [1,2]
The chemical components isolated from D. fragrans have exerted many biological effects [3,4,5,6]
Su [8] reported that Dryofragin, a phloroglucinol derivative from D. fragrans, could stop human osteosarcoma U2OS cells from migrating and invading by lowering MMP-2 and MMP-9 expression and up-regulating the expression of TIMP-2 and TIMP-1 through the p38 MAPK and PI3K/AKT signal pathways
Summary
D. fragrans (Figure 1), from the Dryopteris genus of the Dryopteris family, is a deciduous perennial herb that is mostly distributed in Northeast China, Korea Japan, Russia and North America. [1,2].The chemical components isolated from D. fragrans have exerted many biological effects [3,4,5,6].In recent years, there have been many studies regarding the anticancer components of D. fragrans.Zhao [7] isolated a new coumarin—Dryofracoumarin A—from D. fragrans, which has cytotoxic activity.Su [8] reported that Dryofragin, a phloroglucinol derivative from D. fragrans, could stop human osteosarcoma U2OS cells from migrating and invading by lowering MMP-2 and MMP-9 expression and up-regulating the expression of TIMP-2 and TIMP-1 through the p38 MAPK and PI3K/AKT signal pathways. The chemical components isolated from D. fragrans have exerted many biological effects [3,4,5,6]. There have been many studies regarding the anticancer components of D. fragrans. Zhao [7] isolated a new coumarin—Dryofracoumarin A—from D. fragrans, which has cytotoxic activity. Su [8] reported that Dryofragin, a phloroglucinol derivative from D. fragrans, could stop human osteosarcoma U2OS cells from migrating and invading by lowering MMP-2 and MMP-9 expression and up-regulating the expression of TIMP-2 and TIMP-1 through the p38 MAPK and PI3K/AKT signal pathways. Zhong [9] obtained a novel sesquiterpene—Dryofraterpene A—from D. fragrans, which could significantly inhibit the proliferation of five kinds of cancer cell lines
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
