Abstract
Recently, implantable electrospun nanofiber-based drug delivery devices have acquired a great interest in treating a tissue defect after tumor resection. In current work, Curcumin (CUR) as a natural antitumor agent was incorporated into the mesoporous silica nanoparticles (MSNs), and the CUR-loaded MSNs (CUR@MSNs) were consequently embedded into poly (lactic-co-glycolic acid) (PLGA) via a blending electrospinning process, resulting in an electrospun nanofiber-mediated drug release system (CUR@MSNs/PLGA NFs). The morphology and physicochemical properties of the prepared CUR@MSNs and the composite NFs were characterized through FE-SEM, TEM, TGA, FTIR, BET, and XRD. Also, the in vitro discharge pattern of CUR from the NFs as well as their anticancer efficiency against MCF-7 breast cancer cells was assessed through MTT, wound healing assay, DAPI staining, and qPCR. The obtained results revealed that CUR@MSNs were successfully embedded into the randomly oriented bead-free electrospun PLGA NFs and exhibited a sustained and prolonged drug release profile. Besides, higher cytotoxicity and lower migration with increased apoptosis induction were detected in the cells treated with CUR@MSNs/PLGA NFs. Thus, the fabricated CUR@MSNs/PLGA composite electrospun NFs might attain a safe and highly promising application for potential postsurgical breast cancer treatment.
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