Abstract
With regard to the aim of cancer prevention and/or treatment, a considerable number of basic studies have indicated that dairy and other plant-originated natural food products may possess anticancer activity. On the growth of human leukemia cells, for example, enzymatically digested skim milk or fermented milk cultured with various bacteria can exhibit differential suppressive activities. Our research team has previously revealed that highly ripened cheese was capable of demonstrating strong growth inhibition and induction of apoptotic DNA damage on HL-60 human promyelocyticleukemia cells. In this short review, the available information concerning potent anticancer effects of cheese was summarized. From the stand point of Food Science, functional implications for cancer prevention as well as multifaceted function of cheese are discussed.
Highlights
A concept of food function or functional foods has been raised in Japan [1]
On the growth of human leukemia cells, for example, enzymatically digested skim milk or fermented milk cultured with various bacteria can exhibit differential suppressive activities
Our research team has previously revealed that highly ripened cheese was capable of demonstrating strong growth inhibition and induction of apoptotic DNA damage on HL-60 human promyelocyticleukemia cells
Summary
A concept of food function or functional foods has been raised in Japan [1]. This is one of the emerging fields in Food Science. In view of cancer prevention/treatment, the anticancer effect of functional foods has not been approved in Japan because of the difference among medication and diet. Numerous basic studies have demonstrated that a part of dairy and other plant-originated natural food products may possess anticancer activity [2,3,4]. In view of the cancer prevention, our research group has recently embarked on examining the antiproliferative effect of cheese in HL-60 human promyelocyticleukemic cells as a model. The HL-60 cell line established in 1977 from a patient with acute myeloid leukemia [11], was chosen because of a valid and useful model for discovery of cancer chemopreventive or chemotherapeutic agents from natural products [6,7,12,13,14]
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