Abstract
Cancer is the main cause of death worldwide, so the discovery of new and effective therapeutic agents must be urgently addressed. Diatoms are rich in minerals and secondary metabolites such as saturated and unsaturated fatty acids, esters, acyl lipids, sterols, proteins, and flavonoids. These bioactive compounds have been reported as potent anti-cancer, anti-oxidant and anti-bacterial agents. Diatoms are unicellular photosynthetic organisms, which are important in the biogeochemical circulation of silica, nitrogen, and carbon, attributable to their short growth-cycle and high yield. The biosilica of diatoms is potentially effective as a carrier for targeted drug delivery in cancer therapy due to its high surface area, nano-porosity, bio-compatibility, and bio-degradability. In vivo studies have shown no significant symptoms of tissue damage in animal models, suggesting the suitability of a diatoms-based system as a safe nanocarrier in nano-medicine applications. This review presents an overview of diatoms’ microalgae possessing anti-cancer activities and the potential role of the diatoms and biosilica in the delivery of anticancer drugs. Diatoms-based antibodies and vitamin B12 as drug carriers are also elaborated.
Highlights
Cancer is the major cause of morbidity and mortality worldwide, with an estimated 18.1 million new cases and 9.6 million deaths in 2018 [1]
The results suggest that the induction of early apoptosis in the MDA-MB-231 cells is higher than the late apoptosis and necrosis [42]
The major therapeutic effect is thatthe of biosilica-microparticles only beas discovered in the tumor tissue ofonly micebe treated with drug-loaded achieving tissue‐specificcan treatment, the biosilica‐microparticles can discovered in the tumor and antibody-loaded
Summary
Cancer is the major cause of morbidity and mortality worldwide, with an estimated 18.1 million new cases and 9.6 million deaths in 2018 [1]. Diatoms are rich in minerals, and in the primary and secondary metabolites as the saturated and unsaturated fatty acids, esters, acyl lipids, sterols, proteins, and flavonoids Such as the saturated and unsaturated fatty acids, esters, acyl lipids, sterols, proteins, These compounds have been reported to exhibit anti‐cancer, anti‐oxidant, and anti‐bacterial activities and flavonoids. Diatom cell wall (frustule) contains two thecae over‐lapped structures, akin to a petri‐dish, each half. 3, the diatom cell wall (frustule) contains two thecae over-lapped structures, a valve and different girdle‐bands, extending around the circumference of the cell [19]. Structures, similar to a petri‐dish, half with consisting of a valve and different girdle‐bands, extending around the circumference of the cell, Diatoms with nanopores at different scales (Modified from [13])
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
