Anticancer, Antidiabetic and Antimicrobial Activity Study of Biologically Active Vanadium(IV) Mixed Ligand Complexes

Abstract

Introduction: Cancer and diabetes are proving to be lethal to human society and have attracted attention of researchers around the world. Synthesis of mixed ligand complexes is a challeng-ing area owing to their potential applications as drugs against various diseases. Methods: Synthesis and biological evaluation of mixed ligand complexes of Vanadium(IV) with hetero-cyclic bidentate molecule 8-hydroxyquinoline as primary ligand and L-Amino acids such as L-cysteine, L-alanine, L-phenylalanine, L-threonine and L-serine as secondary ligands is reported here. All the complexes were characterized using IR, electronic, Mass, TGA/DTA method, powder XRD analysis, molar conductance and magnetic susceptibility measurements and were screened for their biological activities. Results: The synthesized mixed ligand complexes were screened for their antibacterial activity against E. coli and antifungal activity against C. albicans. They were also evaluated for in vitro antidibetic ac-tivity, anticancer activity against HepG2 (human liver cancer cell line) by MTT assay. Conclusion: The synthesized mixed ligand complexes were thermally stable, paramagnetic, non-electrolytic in nature and proposed to have square pyramidal geometry. They also exhibited potential as antibacterial, anticancer and antidibetic agents.