Anticancer and photocatalytic antimicrobial assessment of surface engineered titania nanoparticles with modified [formula omitted]-cyclodextrin using thioctic acid

Abstract

The current work reports the fabrication of surface modified titania nanoparticles with a functionalized supramolecular system, such as β-cyclodextrin, and the synthesis of a biocompatible photocatalytic system. β-cyclodextrin is functionalized with thioctic acid by the Steglich esterification method, where the hydroxyl functional group of β-cyclodextrin is coupled with the carboxylic acid group of thioctic acid. This functionalized β-cyclodextrin-thioctic acid conjugate is used for the surface modification of titania nanoparticles. The surface modified titania nanoparticles were examined using Fourier transform infrared spectroscopy, ultraviolet–visible spectroscopy, X-ray diffraction, scanning electron microscopy, transmission electron microscopy and thermal analysis. To examine the photoluminescent properties of the developed nanosystem, steady state fluorescence emission studies were conducted. Using the well diffusion method, photocatalytic antimicrobial studies of the surface modified titania nanoparticles were undertaken. The current study has also discussed the in vitro cytotoxicity and cell viability of the developed system using the trypan blue exclusion method.