Abstract
Objective: To determine the activity of anti-cancer and anti-proliferation of ethyl acetate fraction of ant nest plants (Myrmecodia pendans) in Burkitt’s Lymphoma cancer cells. Material and Methods: The study was conducted in a pure laboratory experimental method using Burkitt's Lymphoma cancer cell culture. Gradual research begins with the determination, extraction and fractionation of ant nest plants, to test for proliferation barriers. Data analysis using two-way ANOVA followed by Post Hoc LSD test with a significance level of 95%. Pearson correlation test was conducted. Results: The results of testing the inhibition of Burkitt’s Lymphoma cell proliferation with ethyl acetate extract treatment showed that there was inhibition of cell growth based on the concentration given, starting from the lowest concentration of 15.625 μg/mL. Likewise, the incubation time factor of 24, 48, and 72 hours showed that the longer the incubation time, the greater the inhibition of cell growth. Antiproliferation analysis of flavonoid ethyl acetate extract based on concentration and incubation time on absorption of optical density Burkitt’s Lymphoma was statistically significant (p = 0.00). Conclusion: Ant nest ethyl acetate extract has the effect of proliferation inhibition on Burkitt’s lymphoma cells.
Highlights
Cancer is a deadly disease and cause of death in industrialized countries and the second cause of death in developing countries
The results showed a significant relations between how much concentration of flavonoid ethyl acetate extract from ant nest plants, incubation time, and how many cells that can survive after being treated with anthyl acetate extracts of ant nests in certain concentrations and times
At 24 hours of incubation time, the concentration of ethyl acetate extracts of ant nests was 15,625 μg/mL, while the number of cells that survived was less than 60 cells
Summary
Cancer is a deadly disease and cause of death in industrialized countries and the second cause of death in developing countries. Cancer is a non-communicable disease, which is characterized by abnormal/persistent, and uncontrolled cell growth, which can damage the surrounding tissues and can spread to places far from their origin called metastasis. According to WHO data in 2013, the incidence of cancer increased from 12.7 million cases in 2008 to 14.1 million cases in 2012, with the number of deaths increasing from 7.6 million people in 2008 to 8.2 million in 2012 [1,2]. Cancer that can cause enlarged lymph nodes is called lymphoma. Lymphoma is a general term for various types of blood cancers that appear in the lymphatic system. According to the 2012 GLOBOCAN (IARC) data, lymphoma is one of the ten most cancers in the world in 2012. Lymphoma is divided into two types, namely Hodgkin's Lymphoma and Non-Hodgkin's Lymphoma. About 90% of lymphoma patients are patients with Non-Hodgkin Lymphoma, and the rest are Hodgkin's Lymphoma [3]
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