Abstract
In a previous study, we reported that 13(E)-labd-13-ene-<TEX>$8{\alpha}$</TEX>,15-diol (13E) possesses antiviral and anticancer activities. In this study, the anticancer and antimicrobial activities of 13(E) were evaluated against 4 cancer cell lines and 6 bacteria. 13(E) showed inhibitory effect on a variety of cancer cell lines. The <TEX>$IC_{50}$</TEX> values was 8.3-21.3 <TEX>${\mu}g/mL$</TEX>. 13(E) was the most effective growth inhibitor of murine leukaemia cell lines P388, producing approximately 8.3 <TEX>${\mu}g/mL$</TEX> of <TEX>$IC_{50}$</TEX> in the cytopathic effect (CPE) method. 13(E) also inhibited the growth of the gram-positive bacteria (Staphylococcus aureus, Bacillus cereus and Listeria monocytogenes) and gram-negative bacteria (Vibrio parahaemolyticus, Escherichia coli and Salmonella enteritidis) with a range of minimum inhibitory concentration (MIC) values from 0.092 to 0.598 mg/mL and gram-negative bacteria were more sensitive to the compound (MIC, 0.092 mg/mL).
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