Abstract
Kefir drink is one of the most important probiotic products, which is made using kefir microorganisms in fermenting the milk. Numerous investigation have been accomplished in the field of the therapeutic property of probiotic products. In the present study, we assessed the cytotoxic effect of kefir on the rate of growth and increase of glioblastoma cancer cell as the most severe form of brain tumors. In this experimental study, we used a U87 cancer cell line (glioblastoma). The interaction between cancer cells and different concentrations of kefir drink and supernatants at 24 and 48 hours was considered. The cell cytotoxicity of kefir and sedimentation of cell lysate and extract of kefir was assessed using the MTT test after 24 and 48 hours. The result of the MTT test, treatment of the cells with the 48-hour fermented drink, demonstrated the most cell cytotoxicity in comparison with the control group. Results showed that the toxicity effect in all groups was dose-dependent, and by increasing the concentration, cell survival decreased noticeably. The results indicated that the supernatant of fermented kefir drink as a probiotic product has more toxicity and lethality effect on the glioblastoma cancer cell. This product can be utilized as a replacement or a complementary therapy of cancer.
Highlights
The central nervous system (CNS) and brain tumors are one of the ten cancers leading to death in Iran
Kefir production is mainly based on the fermentation of milk using starter cultures or kefir grains, which look like small cauliflowers and which contain a complex mixture of lactic acid bacteria, acetic acid bacteria, and yeasts
Kefir is likewise a foodstuff including a collection of probiotic microorganisms that the majority of these probiotics are lactic acid bacteria (LAB)
Summary
The central nervous system (CNS) and brain tumors are one of the ten cancers leading to death in Iran. Eighty percent of primary malignant brain tumors and 30% of all kind of CNS tumors are caused by glioma [3]. A side effect of drugs, time-consuming, costly, and inefficiency of this treatment method, explains the obligation of seeking new therapeutic approaches and solutions for the prevention of suffering from cancer. One of the considerable replacement solutions of treatment and prevention of malignant brain and spinal cord tumors is utilizing microbial products as kefir. The complex microbiota in kefir grains has a symbiotic relationship that is responsible for the characteristic taste and flavour of kefir [5].
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