Anticancer Activity Of Ginger Oleoresin Against Liver cancer Cell Line

Abstract

Zingiber officinale, a medicinal herb belonging to the family Zingiberaceae and native to Southeast Asia, is an herbaceous perennial annual flowering plant. Its extract, ginger oleoresin, is commonly used as a flavoring agent in confectionery and other food products. The HepG2 liver cancer cell line is a useful model for studying cellular regulation, uncontrollable cell proliferation, and limited inhibitory concentration. To investigate the anticancer properties of ginger oleoresin in the HepG2 liver cancer cell line, the present study was conducted. Ginger oleoresin was obtained from Synthite Industries Ltd, Kerala, and MTT assay was performed on HepG2 cell lines to evaluate its anticancer activity. The cells were treated with varying concentrations of ginger oleoresin (20, 40, 60, 80, 100, 200 g/ml) for 24 hours, and cell viability was assessed using MTT assay. The results of the MTT assay revealed that ginger oleoresin exhibited a dose-dependent increase in its anticancer activity against the HepG2 liver cancer cell line. The IC50 value was found to be 35 g/ml. Therefore, within the limitations of this study, it can be concluded that ginger oleoresin possesses a good level of cytotoxic activity against HepG2 cell lines. Further studies using animal models may help establish its effectiveness.