Abstract
We have successfully prepared nanohybrids of biofunctional ferulic acid and layered double hydroxide nanomaterials through reconstruction and exfoliation-reassembly routes. From X-ray diffraction and infrared spectroscopy, both nanohybrids were determined to incorporate ferulic acid molecules in anionic form. Micrsocopic results showed that the nanohybrids had average particle size of 150 nm with plate-like morphology. As the two nanohybridization routes involved crystal disorder and random stacking of layers, the nanohybrids showed slight alteration in z-axis crystallinity and particle size. The zeta potential values of pristine and nanohybrids in deionized water were determined to be positive, while those in cell culture media shifted to negative values. According to the in vitro anticancer activity test on human cervical cancer HeLa cells, it was revealed that nanohybrids showed twice anticancer activity compared with ferulic acid itself. Therefore we could conclude that the nanohybrids of ferulic acid and layered double hydroxide had cellular delivery property of intercalated molecules on cancer cell lines.
Highlights
Organic-inorganic nanohybrids in which functional organic molecules were homogeneously combined with inorganic materials in nanoscale have attracted great interests in many research and industry fields [1, 2]
As the layered double hydroxides (LDHs) was 2-dimensional layered inorganic material of which interlayer ions existed through electrostatic interaction with layers, the interlayer distance could be varied according to the size of interlayer anions
We have demonstrated the physico-chemical property and biological activity of ferulic acid (FA)-LDH nanohybrids
Summary
Organic-inorganic nanohybrids in which functional organic molecules were homogeneously combined with inorganic materials in nanoscale have attracted great interests in many research and industry fields [1, 2]. 2D layered materials, such as layered double hydroxides (LDHs), are known to have physical strength [3], chemical inertness [4], highly anisotropic structure [5], biocompatibility [6], pH-dependent solubility [7], and high cellular uptake efficiency [8] and the intercalation of biofunctional molecules into LDHs has been known to enhance their biological availability [8, 9]. When a part of M(II) cations in M(II)(OH) structure is isomorphically substituted with M(III) ones, there evolves permanent positive charge on the framework. In this way, the layer of LDHs acquires positive layer charge which is compensated by the anions. Various kinds of biomolecules such as deoxyribonucleotides, oligonucleotides, anticancer drugs, antibiotics, vitamins and antioxidants have been
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