Anticancer Activity of Adathoda vasica in Hela, HepG2, MCF-7, MDAMB-231 Cell Lines- In vitro

Abstract

This study was undertaken to evaluate the effect o methanolic extract of the leaf of Adhatoda vasaka on different cancer cell lines like MCF-7, MDA- MB-231, Hela, HepG2 cell lines. The ethanolic extract of Adhatoda vasica was tested for its anticancer cytotoxic properties in vitro on a variety of cancer cell lines, including MCF-7, The active constituents carbohydrates, steroids, Alkaloids, Tannins, Flavanoids, Saponins, gums and mucilage. The ethanolic extract of Adhatoda vasica showed a good cytotoxic activity (60%, 60%, 85% and 65%) in Hela, HepG2, MCF-7, MDAMB-231 cells at 24 hrs respectively. In this In-vitro studies the normal cells are act as a positive control. The ethanolic extract of Adhatoda vasica shows maximum percentage of 85% after 24 hrs. From this study, it can be concluded that the phytoconstituents of Adhatoda vasica have significant anticancer-cytotoxic activity on Hela, HepG2, MCF-7, MDAMB-231 cells. According to the findings of the current investigation, the Adhatoda vasica Methanolic extract showed anti-cancer activity only in the plant's leaf extract, which was successful. At doses of 200 mg per kilogramme and 400 mg per kilogramme of body weight, Linn., leaf significantly inhibits the growth of MCF-7, MDA MB-231, HeLa, and HepG2 cells.