Abstract
The aim of the present investigation was to evaluate the effect of A. nilotica extract against Dalton's ascitic lymphoma (DAL) induced solid and ascitic tumors in BALB/c mice. Experimental animals received A. nilotica extract (10 mg/kg.bw) intraperitoneally for 10 and 14 consecutive days before induction of solid and ascitic tumors, respectively. Treatment with A. nilotica extract significantly decreased the development of tumor and percentage increase in body weight when compared to DAL induced solid tumor control group, also increasing the life span, restoring the total white blood cell count and hemoglobin content and significantly decreasing the levels of serum aspartate transaminase (SGPT), alanine transaminase (SGOT), alkaline phosphatase (ALP), gamma glutamyl transferase (GGT) and nitric oxide (NO) when compared to DAL induced ascitic tumor controls. The treatment also reduced significantly the cellular glutathione (GSH) and nitric oxide levels in treated animals. Histopathological studies also confirmed protective influence. The outcome of the present work indicates that A. nilotica extract could be used as natural anticancer agent for human health.
Highlights
Over the past decade, Cancer is the leading cause of death worldwide and it is characterized by uncontrolled growth and spread of abnormal cells
Treatment with A.nilotica extract significantly decreased the development of tumor and percentage increase in body weight when compared to Dalton’s ascitic lymphoma (DAL) induced solid tumor control group, increasing the life span, restoring the total white blood cell count and hemoglobin content and significantly decreasing the levels of serum aspartate transaminase (SGPT), alanine transaminase (SGOT), alkaline phosphatase (ALP), gamma glutamyl transferase (GGT) and nitric oxide (NO) when compared to DAL induced ascitic tumor controls
Effect of A.nilotica extract on solid tumor development and body weight in DAL induced mice
Summary
Cancer is the leading cause of death worldwide and it is characterized by uncontrolled growth and spread of abnormal cells. Treatment of cancer varies according to each type, has been facing large number of problems. Several ways in the treatment of cancer have been developed. Even a large number of tumors are scantily responsive to cancer therapeutic drugs and radiotherapy. Identification and development of natural products used for cancer prevention have attracted a lot of attention globally. Herbal extracts with their proven potential and less side effects in therapeutics has replaced the synthetically derived drugs in modern allopathic medication system (Sakthivel and Guruvayoorappan, 2012). Traditional healers of different regions in India Chhattisgarh used Acacia species for treatment of various cancer types of mouth, bone and skin (Kalaivani and Mathew, 2010)
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