Abstract
Lymphoid cells from nonsensitized donors can be cytotoxic in vitro for target cells coated with antibody. The antibody can be directed either against antigens which are intrinsic to or experimentally attached to the target cell surface. Killing of target cells by this method has been termed antibody-dependent cell-mediated cytotoxicity (ADCC). In these investigations we compared the ability of Peyer's patch cells and spleen cells from nonsensitized mice to lyse lipoplysaccharide-coated and uncoated target cells by an ADCC mechanism. The results demonstrate that spleen cells, but not Peyer's patch cells, from identical mice can be cytotoxic for lipopolysaccharide-coated chicken erythrocytes (CRBC) in the presence of anti-lipopolysaccharide antibody and uncoated CRBC in the presence of anti-CRBC antibody. Thus, Peyer's patches in mice appear to be deficient in the effector cell type(s) required to kill antibody-coated erythrocyte target cells by an ADCC mechanism as well as the macrophage-like accessory adherent cell type(s) required for the induction of humoral antibody synthesis and cell-mediated cytotoxic allograft reactions in vitro.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
