Abstract
This project concerns a new strategy of detecting biological molecules that relies on competitive exchange interactions of an analyte with two-component molecular tethers attaching superparamagnetic microspheres (4 micron in diameter) to a sensor surface. The individual tethers consist of either double stranded DNA or antibody-antigen complex and are designed to selectively detect either specific ssDNA or antigenic proteins, respectively, in sensitive reagentless fashion. Performance of sensors was investigated using human cardiac troponin I, a serum heart attack marker, as an example of analytes of credible relevance to biomedical diagnostics.
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