Abstract
Red cell unexpected alloantibodies can be present in healthy donors who were either transfused previously or pregnant previously. Presence of irregular erythrocyte alloantibodies can occasionally cause severe transfusion reaction if a large amount of plasma or whole blood is transfused as in massive transfusions and in pediatric patients. Here we are presenting a case report of a donor who had red cell alloantibody. The purpose of highlighting this case report is to know the significance of detecting irregular erythrocyte antibodies in healthy donors.
Highlights
There are two types of antibodies that are of concern in blood banking: one is naturally occurring and the other is immune
RBC antibodies are considered naturally occurring when they are found in the serum of individuals who have never been previously exposed to RBC antigens by transfusion, injection, or pregnancy
There is a low prevalence in normal healthy donor population, but the significance of irregular erythrocyte antibodies can be that large amount of plasma or whole blood is transfused as in massive transfusions and in paediatric patients
Summary
A 37 years old male donor came to us for donating blood at our blood bank. On testing his blood group it was found “A Rh D negative”. On putting indirect antiglobulin test (IAT) of donor serum with pooled O cell it was found positive. Select cell panel test confirmed the above findings. When the donor was asked for a detail history of transfusion it was found that he was transfused 12 years back for fracture femur surgery. Donor informed us that at that time A Rh D negative blood was not available in the inventory of the hospital so that they transfused with A Rh D positive to him.
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