Abstract
Female guinea pigs, inoculated intravaginally with a herpes simplex virus-type 2 (HSV-2) strain M1, developed typical symptoms of a primary and recurrent genital herpes infection. Sera from HSV-2 infected guinea pigs taken during the primary or recurrent stages of the genital infection contained complement (C)-fixing antibody which reacted with an apparent type specificity to an early 4 h HSV-2 infected cell extract (AG-4) when compared to a 4 h HSV-1 infected cell extract. This C-fixing anti-AG-4 activity was shown to be associated with the IgG2 subclass and directed primarily against HSV-2 infected cell polypeptide (ICP)6 and ICP8. Furthermore, C-fixing anti-AG-4 levels remained constant after the primary infection and during recurrences for over 6 months. Thus, while the anti-AG-4 response in guinea pigs was of the IgG type, it varied from that found previously in human genital HSV-2 sufferers which was of the IgM type. Also, while an IgG anti-AG-4 response in human genital HSV-2 sufferers is associated with a reduction in the number of recurrences, this reduction is not apparent in the guinea pig model.
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