Abstract
The RNA bacteriophage Qβ, reconstituted phage, and a coat protein monomer-succinylated lipopolysaccharide complex were highly immunogenic in rabbits as estimated by passive hemagglutination procedures in which rabbit erythrocytes were coated with the intact virus. The coat protein monomer was slightly immunogenic whereas the coat protein aggregate and the RNA were nonimmunogenic. The peak antibody response to the reconstituted phage and to the coat protein monomer-succinylated lipopolysaccharide complex were slightly lower than that of the whole phage. It appeard that the immunogenicity of the phage was dependent upon a specific quarternary structure imparted to the coat protein momer by the RNA or succinylated lipopolysaccharide.
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