Abstract
An antigen fraction (Dssd I) was isolated from the aqueous-insoluble components of adult Setaria digitata. Rabbit antiserum to Dssd I labeled the sheaths of Wuchereria and Setaria microfilariae suggesting Dssd I to be surface associated. Antibody responses to Dssd I were determined in Wuchereria bancrofti exposed individuals. IgM titre was highest in endemic normals (EN; asymptomatic amicrofilaraemic) followed by chronic filarial patients (CP) and asymptomatic microfilaraemics (AS). IgG titer was high in both chronic filariasis and endemic normals. The microfilaraemic group had the lowest titer. The seropositivity rate in AS was 28% for IgG and 10% for IgM, in CP 100% for IgG and 33% for IgM, and in EN 86% for both antibodies. An age-dependency of IgM but not of IgG antibodies was observed in endemic normals, with IgM prevalence reaching a plateau by 12 years of age. The subclass composition of the antibody response to Dssd I appeared to be primarily IgG 3 in endemic normals, IgG 1 in chronic filariasis and IgG 4 in asymptomatic microfilaraemics. Diethylcarbamazine (DEC) treatment led to a significant increase in IgG and IgM levels in microfilaraemic individuals. Of interest, the expression of IgG subclasses altered. There was an increased IgG 3 and IgG 1 response associated with a reciprocal decrease in IgG 4 following DEC therapy.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
