Abstract
Antibody production by a protease-deficient strain of methylotrophic yeast, Ogataea minuta
Highlights
At present the expression system of mammalian cells such as CHO has been adopted as the conventional method to produce antibody for pharmaceuticals
The 4th Recombinant Protein Production Meeting: a comparative view on host physiology The organisers would like to thank Novozymes Delta Ltd who generously supported the meeting. Meeting abstracts – A single PDF containing all abstracts in this supplement is available here http://www.biomedcentral.com/content/pdf/1475-2859-5-S1-info.pdf
When human antibody genes were introduced in the methylotrophic yeast O. minuta to produce an antibody, the heavy chain of the antibody was partially degraded
Summary
At present the expression system of mammalian cells such as CHO has been adopted as the conventional method to produce antibody for pharmaceuticals. Antibody production by a protease-deficient strain of methylotrophic yeast, Ogataea minuta Kousuke Kuroda*1, Yoshinori Kitagawa[1], Kazuo Kobayashi[1], Haruhiko Tsumura[1], Toshihiro Komeda[2], Yasunori Chiba[3] and Yoshihumi Jigami[3] Address: 1Kirin Brewery Co., Ltd., CMC R&D Lab, Gunma, Japan, 2Kirin Brewery Co., Ltd., Central Lab for Frontier Technology, Kanagawa, Japan and 3National Institute Advanced Industrial Science and Technology (AIST), Ibaragi, Japan * Corresponding author from The 4th Recombinant Protein Production Meeting: a comparative view on host physiology Barcelona, Spain.
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