Abstract
Antibody formation against antigen-recognizing receptors of T lymphocytes were shown to be capable of being formed in a syngeneic system. Antiserum of CBA mice receiving intravenous injections of CBA lymphocytes immune against C57BL cells specifically inhibited blast transformation of CBA T lymphocytes against C57BL cells only in a mixed culture. The same antiserum had no effect on proliferative actiivy of CBA T lymphocytes reacting to “foreign antigen” — i.e., DBA/2 cells. No antibodies against C57BL cells likewise were found in the antireceptor antiserum. A regulatory influence of autoantireceptor antibodies on the immune response is postulated.
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