Abstract
We report a young child with hypoplastic anemia and antibody deficiency with normal serum immunoglobulin levels. Studies of antibody responses to bacteriophage φX 174 revealed an amnestic response but was predominantly limited to IgM. A similar response was observed following booster tetanus toxoid immunization. Analysis of in vitro pokeweed mitogen-induced immunoglobulin synthesis by the patient's B cells suggested an intrinsic B-cell defect.
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