Abstract
OBJECTIVE. The authors evaluated the role of antibodies to striated muscle and acetylcholine receptors in diagnostics of myasthenia gravis and thymoma, as well as outcomes of thymectomy and prognosis of myasthenia course. MATERIAL AND METHODS. The study investigated correlations of antibody content to striated muscles and acetylcholine receptors from the presence and size of thymoma, myasthenia in 157 patients with various pathologies of the thymus. The dynamics of antibody concentrations was followed up after thymectomy. RESULTS. Antibody titer to striated muscle depended on the presence and size of thymoma, severity of myasthenia and changed after thymectomy. Concentration of antibodies was associated with the presence of thymoma and it didn’t change after surgical treatment. Thymoma wasn’t revealed in patients who were seronegative to both antibodies. CONCLUSIONS. Seropositivity according to one of antibody could indicate the presence of thymoma, but its absence to both antibodies allowed doctors to eliminate this diagnosis. Antibodies to acetylcholine receptors are important markers of myasthenia. Monitoring of antibody titer dynamics to striated muscles after thymectomy could be useful for assessment of response to surgical treatment and prognosis of course of myasthenia.
Highlights
Antibodies to striated muscle and acetylcholine receptors in evaluation of surgical treatment outcomes in patients with autoimmune myasthenia gravis
The authors evaluated the role of antibodies to striated muscle and acetylcholine receptors in diagnostics of myasthenia gravis and thymoma, as well as outcomes of thymectomy and prognosis of myasthenia course
Acetylcholine receptor antibody and clinical response to thymectomy in myasthenia gravis // Neurology
Summary
Изучение роли антител к скелетным мышцам и ацетилхолиновым рецепторам в диагностике аутоиммунной миастении и тимом, оценке эффективности тимэктомии и прогнозировании течения миастении. У 157 пациентов с различными заболеваниями вилочковой железы изучена зависимость содержания антител к скелетным мышцам и ацетилхолиновым рецепторам от наличия и размера тимомы, от миастении, а также динамика содержания этих антител после тимэктомии. Титр антител к скелетным мышцам зависел от наличия и размера тимомы, тяжести миастении, изменялся после тимэктомии. Содержание антител к ацетилхолиновым рецепторам зависело также от наличия тимомы, однако не изменялось после хирургического лечения. Изучение динамики титра антител к скелетным мышцам после тимэктомии может быть полезным для оценки ответа на хирургическое лечение и прогноза течения миастении. Ключевые слова: аутоиммунная миастения, тимома, антитела к скелетным мышцам и ацетилхолиновым рецепторам, тимэктомия
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
