Abstract
Two rabbits were repeatedly injected with partially purified thyrocalcitonin, a hypocalcemic principle extracted from porcine thyroid glands. The hypocalcemic activity of porcine thyrocalcitonin in the intact rat was neutralized completely by incubation with serum obtained from the injected rabbits. No loss of hypocalcemic activity occurred during incubation of thyrocalcitonin with control rabbit sera. It is tentatively concluded, on the basis of the following evidence, that the factor in the serum of the injected rabbits that neutralized the hypocalcemic activity of thyrocalcitonin is antibody to thyrocalcitonin. 1) The titer of the neutralizing factor in rabbit serum was shown to rise with repeated injections of thyrocalcitonin. 2) Hypocalcemic activity was recovered from the precipitate which formed during incubation of thyrocalcitonin with immune rabbit serum. 3) The factor did not indiscriminately neutralize the hypocalcemic activity present in extracts of thyroid glands obtained from all species. 4)...
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