Abstract
Aspergillus and Penicillium species produce extracellular polysaccharides (EPS) of which (1→5)‐interlinked β‐D‐galactofuranosides are immunodominant. Synthetic tetra‐ and heptamers of (1→5)‐interlinked P‐D‐galactofuranosides conjugated to tetanus toxoid were used to produce antibodies in rabbits. The antibodies obtained with the tetramer conjugate reacted only with EPS of a few Penicillium and Aspergillus species. Antibodies obtained with the heptamer conjugate were reactive with EPS of all the Penicillium and Aspergillus species tested. The reaction with P. digitatum EPS could be inhibited by the synthetic heptamer of β‐(1→5) interlinked galactofuranosides. No reactions were observed with EPS of moulds belonging to any other genus.
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