Abstract
Antibodies are a promising tool for studying and isolating ion channels of cellular membranes. We can suppose also that monoclonal antibodies are an effective instrument to regulate the dependence of functioning of ionic channel gates on the electric field in the membrane as well as to change the ion-conducting properties of single channels in the open state. However such studies are difficult because the mechanism of antibody — channel interaction as well as the structure of cell membrane channels have not yet been understood enough. The investigation of this mechanism can be facilitated by the study of the action of antibodies on an ion channel with the known structure and properties. Two different ionic pores were chosen to be such channels: (1) the ionic pore formed by the polyene antibiotic amphotericin B and cholesterol in a bimolecular lipid membrane, (2) the ionic pore formed by the polypeptide β-1atrotoxin.
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