Abstract

Antibiotic usage has become very widespread, as they are used to treat so many infectious diseases today. Antimicrobial agents exert their actions via different mechanisms including blockage of cell wall synthesis, interference of protein and/or nucleic acid synthesis, interruption of cell membrane structure, and inhibition of a metabolic pathway.

Highlights

  • Pathogenic microorganisms have negatively affected human health throughout history

  • The majority of patients believe that their risk of bacterial resistance increases if they take an antibiotic on a regular basis and they are not at risk if they are not on any antibiotics [14]

  • The vaccination programs against Haemophilus influenzae and Streptococcus pneumoniae have been very effective in significantly reducing bacterial infection; there are some concerns about the emergence of bacterial resistance against these vaccines

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Summary

Introduction

Pathogenic microorganisms have negatively affected human health throughout history. A significant percentage of human population has been affected by bacterial infections (e.g., bubonic plague and tuberculosis) and non-bacterial infections (e.g., malaria and HIV) pandemics [1]. With the discovery of penicillin and some other classes of antibiotics in twentieth century, they were considered miracle drugs. In the twenty-first century, antibiotics are still being used, but with much less success. Many factors contributed to antibiotic resistance that made the antibiotics less effective

Antibiotics overuse
Lack of regulations
Lack of optimization
Factors associated with healthcare professionals
Factors associated with patients
Use in agriculture
Use of cleaning products
Mechanisms of Antibiotics Resistance
Antibiotics targeting cell wall
Inhibitors of protein biosynthesis
Folic acid metabolism inhibitors
Interference with nucleic acid synthesis
Disruption of bacterial membrane structure
Role of Antibiotics on Microenvironment and Immune Response
Cost of Antibiotic Resistance
The Solution
Patients education
Role of healthcare professionals
Diagnostic techniques
Optimization of use
Route of administration
Alternative options
Current global efforts
Future research studies
Conclusion
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