Abstract

ABSTRACT Background Evaluating antibiotics most commonly associated with pseudomembranous colitis (PMC) based on the real-world data is of great significance. Research design and methods We used the data from FAERS to evaluate the potential association between antibiotics and PMC by disproportionality analyzes. Results Eighty-one antibiotics which met the three algorithms simultaneously were enrolled. There were 1683 reports of PMC associated with the enrolled antibiotics. In the top 24 antibiotics, cefoxitin, streptomycin, fosfomycin, and micafungin had a high risk of PMC, but there were few reports in the literature. Conclusions This study was of great significance for healthcare professionals to realize the potential PMC risks of antibiotics.

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