Abstract
In view of the lack of concurrence among several investigators concerning a possible in vivo antithyroid effect of Aureomycin® and penicillin, the surviving thyroid slice method in use in this laboratory for several years has been employed to test the direct antithyroid action of some common antibiotics. Although the agents (PAS and isoniazid) frequently employed in treating tuberculosis have been found to exert a significant antithyroid activity, none of the common antibiotics tested exhibited an antithyroid effect except at concentrations higher than those to be expected in clinical practice.
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More From: Journal of Pharmaceutical Sciences (Scientific Edition)
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