Abstract
Drug therapy is one of the most important factors in providing community health. In a proper selection of an antibiotic for curing an infection, the kind of infective agent and its sensitivity to the utilized drugs must be regarded. The patients whom are admitted in ICUs are 5 to 7 folds more vulnerable to infection. The studies has been done in past decades have shown various amounts of inappropriate antibiotic use. The files of 234 patients whom were admitted during 6 months in ICUs (Surgery, Neurosurgery, Neurology and Pulmonary diseases) of Imam Reza Hospital of Tabriz County studied for manner of antibiotic therapy, antibiotic changes during therapy, number of prescribed antibiotics 64% of patients were male and 36% were female. Average age of patients was 43.9±23.9 years. The most admission of patients was in Surgery ICU (69.2%). The most prescribed antibiotic was Cephalosporin family and ceftriaxone was the most utilized antibiotic. In 59.7% of patients, the antibiotics were prescribed empirically and in 35% of cases antibiotics changed during treatment. 28.1% of cases treated with monotherapy while others treated with combination therapy. In 61% of cases, the prescribed antibiotics were inappropriate with final diagnosis of patients. The majority of antibiotics were prescribed according to physician’s clinical experiment and combination therapy is used much more than monotherapy.
Highlights
Medical therapy is one of the routines in treatment of the patients so the logical administration of drugs is one of the most important contributing factors providing the health of the communinty
There was no similar study in this regard, but in a study, which had evaluated the effect of antibiotic therapy on final clinical results in patients with bacteremia, the results showed that the lengthening the time of antibiotic therapy makes no significant difference on clinical results (Havey et al, 2011)
Upon the results of the present study, Cephalosporin’s is the most common antibiotic class and Ceftriaxone was the most commonly used antibiotic in ICU sections of Tabriz Imam Reza hospital
Summary
Medical therapy is one of the routines in treatment of the patients so the logical administration of drugs is one of the most important contributing factors providing the health of the communinty. Antibiotics are of most important drug agents with great role in health providing, if not administrated logically beside its useful effects, these agents can harm the health of the communities and humans with their side effects (Diaz-Martin et al, 2012). Corresponding Author: Sepehr Taghizadeh, Infectious Diseases and Tropical Medicine Research Center, Faculty Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Sepehr Taghizadeh et al / American Journal of Infectious Diseases 9 (4): 130-135, 2013 underlying diseases were studied. In the normal health situation can be treated with an antimicrobial agent but due to better antimicrobial coverage of combination therapy, some physicians prefer the combination therapy with 2 or 3 antibiotics but it should be considered that inappropriate use of such therapies can result in adverse effects (Leibovici et al, 1998)
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