Abstract
Klebsiella pneumoniae is a pathogen of the Enterobacteriaceae family that causes healthcare-associated infections and has recently emerged as one of the most antibiotic-resistant organisms responsible for outbreaks in both community and healthcare settings. The aim of this study is to determine the resistance pattern of Klebsiella pneumoniae isolated from selected tertiary hospitals in Osun state, Nigeria. A total of 62 Klebsiella pneumoniae isolates were obtained from 1056 samples of urine, wound swab, ear swab, eye swab and other collection sites that were routinely submitted to the diagnostic laboratories of the selected tertiaryhospitals. Susceptibility to twelve (12) antibiotics (Oxoid) was determined using the Kirby Bauer disk diffusion method for the 62 isolates. Rate of resistance to carbapenems, fluoroquinolones, polymyxins, monobactams, cephalosporins, penicillin and phosphonic acid derivative are 29.03%, 47.84%, 29.03%, 46.77%, 50.80%, 93.55%, and 37.10% respectively. The isolates were mostly susceptible to carbapenems, especially, Imipenem with 74.19%. Highest resistance was to Penicillin (93.55%). The multiple antibiotic resistance (MAR) index revealed that 52 (83.87%) out of 62 isolates were multi-drug resistant. Increase in antibiotic resistance continues to be a problem amidst patients infected with Klebsiella pneumoniae which can be most likely attributed to increase in antibiotic misapplication, misuse and abuse which is most prevalent among youths. It is therefore of utmost importance that consistent monitoring of antibiotic resistance be done as it will assist in the appropriate selection of empiric antibiotic treatment in the proper setting.
Highlights
Klebsiella pneumoniae is a pathogen of the Enterobacteriaceae family that causes healthcareassociated infections and has recently emerged as one of the most antibiotic-resistant organisms responsible for outbreaks in both community and healthcare settings [1]
This study aimed at determining the drug susceptibility of Klebsiella pneumoniae isolated from selected tertiary hospitals in Osun state, Nigeria, so as to assist in the appropriate selection of empiric antibiotic treatment for infections caused by Klebsiella pneumoniae
3.1 Distribution of Klebsiella pneumoniae isolated from selected hospitals in Osun state
Summary
Klebsiella pneumoniae is a pathogen of the Enterobacteriaceae family that causes healthcareassociated infections and has recently emerged as one of the most antibiotic-resistant organisms responsible for outbreaks in both community and healthcare settings [1]. Iraqi Journal of Science, 2019, Vol 60, No., pp: 1423-1429 rise to the emergence of antibiotic-resistant isolates, leading to very detrimental problems in the affected individuals and in the community at large [5], as the treatment outcome of the infection would be affected by the presence of drug resistance in the infecting pathogen [4]. This can lead to prolonged stay in the hospital [6], cause a drastic increase in health care costs and in many cases, results in life-threatening and untreatable infections [7]. This study aimed at determining the drug susceptibility of Klebsiella pneumoniae isolated from selected tertiary hospitals in Osun state, Nigeria, so as to assist in the appropriate selection of empiric antibiotic treatment for infections caused by Klebsiella pneumoniae
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