Antibiotic sensitivity pattern of coagulase negative staphylococci in a tertiary care hospital of Southern Rajasthan

Abstract

Coagulase negative staphylococci have been recognized as one of the important cause of hospital acquired infections in recent past. It has become difficult to manage these infections due to emergence of multidrug resistance to them. The aim of this study was to determine antibiotic sensitivity trend of all Coagulase negative Staphylococci isolates using modified Kirby- Bauer disk diffusion technique. To assess the antibiotic sensitivity for coagulase negative staphylococci, Kirby-Bauer disc diffusion method on Muller-Hinton agar was used. The study findings were interpreted on the basis of CLSI standards. All coagulase negative staphylococci isolates were given a predetermined panel of antibiotics. Methicillin-resistant coagulase negative staphylococci were identified using Cefoxitin disk. The sensitivity to Linezolid, Vancomycin and Rifampicin was found in all 500 isolates of coagulase negative staphylococci in our study. However, they were resistant to Penicillin G (65%), Cefoxitin (56%), Ciprofloxacin (57%), Levofloxacin (32%), Gentamicin (21%), Erythromycin (67%), Clindamycin (60%), Cotrimoxazole (51%) Tetracycline (9%). As CoNS have emerged as an important agent of hospital acquired infections, hence there is need of identification, speciation and resistance pattern of isolates for better management of patients.