Abstract
Introduction: Antibiotics resistance is increasing nowadays. Factor to antibiotic resistance is its misuse. There is no national guideline for use of antibiotics.
 Objective: Study was conducted to determine bacteriological profile, and the bacterial antibiotic sensitivity pattern of the pathogens isolated from patients in intensive care unit.
 Methodology: Study was conducted between 1st October 2020 and 30th March 2021. The samples collected from Intensive care units patients were processed in Microbiology Laboratory following Clinical and Laboratory Standard Institute guideline. Organisms were identified morphologically and biochemically and antibiotic sensitivity pattern was determined by disc diffusion methods.
 Result: Out of total 397 samples, only 46 were found to be culture positive, of which 32 (69.56%) were gram negative organisms and 14 (30.43%) were gram positive organisms. Out of gram negative organisms Klebsiella pecies 10 (21.73%) were predominant which is more sensitive to colistin, polymyxin B and tigecycline. Among gram positive organisms Staphycoccus aureus 12 (85.71%) was found more sensitive to Vancomycin than others.
 Conclusion: It is concluded that Klebsiella species and Staphylococcus aureus were predominant pathogens isolated from the patients. Regular surveillance of antibiotic sensitivity pattern and stewardship program will be useful in treating patients in Intensive care unit.
Highlights
Organisms were iden fied morphologically and biochemically and an bio c sensi vity pa ern was determined by disc diffusion methods
It is concluded that Klebsiella species and Staphylococcus aureus were predominant pathogens isolated from the pa ents
Regular surveillance of an bio c sensi vity pa ern and stewardship program will beuseful in trea ng pa ents in Intensive care unit
Summary
Microbes are the organism that causes infec ons.[1]. The major cause of mortality worldwide is infec on which targeted low and lower middle countries.[2]. Infec on is common among hospitalized pa ents of intensive care unit.[3,4]. Rather than other hospital pa ents, Intensive care unit pa ents are 5-10 mes more likely of acquiring hospital infec on.[6]. Health care associated infec on is high risk factor with cri cally ill pa ents in Intensive Care Unit which occurs due to various factors like decreased host defences, use of devices and due to cross transmission of infec on among pa ents and staffs.[7,8]. Health care associated infec on and an bio c resistance are prime treats among pa ents in ICU.[9]. ICU pa ents acquiring infec ons are mostly associated with invasive devices and ven lators.[12]. Infec ons caused by gram nega ve bacteria in ICU has increased with which lack of treatment op ons against mul drug resistant (MDR) strains is in doubt. Infec on that is caused by MDR gram nega ve organisms brings high morbidity and mortality. An microbial Stewardship programs can op mize the proper use of available an microbial agent which can improve infec ons caused by organisms
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