Antibiotic Sensitivity Pattern in Neonatal Septicemia at Tertiary Care Hospital

Abstract

Background: There is real shortage of national data on antimicrobial resistance rates in Indian neonates. A descriptive review was conducted to determine the patterns of antimicrobial resistance in isolates of blood stream infection among neonates in Jamnagar, Gujarat, India. Materials and Methods: The study was carried out in a tertiary care hospital from a period of March 1, 2014, to August 31, 2015. This is a non-randomized, prospective study in which 109 cases of suspected neonatal septicemia on the basis of antenatal high-risk factors and signs and symptoms of sepsis during this period were studied. Results: A total number of 109 neonates with clinically suspected neonatal septicemia were studied. Sixty-nine (63.3%) cases out of them were blood culture positive. Out of 69 positive cases, in one sample, two organisms were isolated. Hence, the total number of organisms was 70. Out of these 70 organisms, 44 were Gram-positive cocci, 23 were Gram-negative bacilli, and three were Candida spp. Gram-positive cocci were more sensitive to linezolid, vancomycin, and clindamycin whereas Gram-negative bacilli were more sensitive to ampicillin, ofloxacin, and amikacin. Antimicrobial sensitivity of fungal isolates was not done as the antifungal discs were not available. Conclusion: The Gram-positive organisms are the frequent cause of neonatal septicemia so when neonatal septicemia is suspected, drugs of choice for Gram-positive organisms are linezolid, vancomycin, and clindamycin and for Gram-negative organism drugs of choice are ampicillin, ofloxacin, and amikacin.