Abstract
Blood Stream Infection (BSI) and Urinary Tract Infection (UTI) being leading causes of morbidity and mortality represent a common complication among critically ill patients. During the last decade, clinicians have observed a rising occurrence of BSIs due to bacterial resistance. Likewise, catheter-associated UTI is a main cause of morbidity and mortality affecting all age groups. Coliforms happen to be the prominent pathogens among our ICU admitted patients. It was alarming to notice 42.9% resistance to tigecycline among K. pneumoniae isolated from blood. K. pneumoniae isolates cultured from urine of ICU patients uniformly displayed 75% resistance to ciprofloxacin, ceftriaxone, cefoxitin and cefepime. Interestingly, it is of respite to observe 85.7% K. pneumoniae isolated from blood and 75% K. pneumoniae isolated from urine being susceptible to a conventional antibiotic, gentamicin. Escherichia coli isolated from urine were 100% susceptible to carbapenems and 91.75% were susceptible to tigecycline. Overall, 90% of Pseudomonas aeruginosa were susceptible to nitrofurantoin. The rapid spread of these MDR pathogens demands for national and regional guidelines. Policies to treat ICU related infections in UAE should be designed based on local microbiological data and resistance profiles of pathogens.
Highlights
In spite of controlling many risk factors, there is higher risk of infections in intensive care units (ICUs) compared with regular wards
K. pneumoniae isolates cultured from urine of ICU patients uniformly displayed 75% resistance to ciprofloxacin, ceftriaxone, cefoxitin and cefepime
It is of respite to observe 85.7% K. pneumoniae isolated from blood and 75% K. pneumoniae isolated from urine being susceptible to a conventional antibiotic, gentamicin
Summary
In spite of controlling many risk factors, there is higher risk of infections in intensive care units (ICUs) compared with regular wards. In comparison to pneumonia and wound infections, BSI and UTI have a higher incidence in ICUs compared with other wards. Patients with asymptomatic bacteriuria harbor major pool of antibiotic resistant pathogens in hospitals[12]. With this background in mind, we designed this study with the following aim: to study the prevalence of BSIs and UTIs caused by antibiotic resistant bacterial pathogens among ICU Patients. The objectives of the study were to analyze the types of bacterial isolates cultured from blood and urine samples of ICU patients; to determine the bacterial drug resistance profile and to understand the bacterial resistance pattern among BSI and UTI causing pathogens from ICU in past 2 years
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