Abstract
NICE guidance written in 2008, and revised in 2015, no longer recommends antibiotic prophylaxis in patients at high-risk of infective endocarditis who are undergoing high-risk dental procedures. This guidance is different from every international guideline, including a 2015 European Society of Cardiology revision. The European guideline committee considered, but rejected, the NICE view. How has this important difference in advice arisen and what are its implications?
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