Abstract
We read with great interest the recent editorial by Schein.1Schein O.D. Prevention of endophthalmitis after cataract surgery: making the most of the evidence.Ophthalmology. 2007; 114: 831-832Abstract Full Text Full Text PDF PubMed Scopus (22) Google Scholar We commend the sound analysis of the available evidence regarding the prevention of endophthalmitis and, in particular, appreciate his emphasis on the value of a methodological approach to evaluating research evidence.However, we note that the author erroneously mentioned cefazolin as the intracameral antibiotic used in the European Society of Cataract & Refractive Surgeons randomized control trial of prophylaxis of postoperative endophthalmitis after cataract surgery.2Barry P. Seal D.V. Gettinby G. et al.ESCRS study of prophylaxis of postoperative endophthalmitis after cataract surgery: preliminary report of principal results from a European multicentre study.J Cataract Refract Surg. 2006; 32: 407-410Abstract Full Text Full Text PDF PubMed Scopus (313) Google Scholar Intracameral cefuroxime was the antibiotic employed in the study, and we think this is an important distinction, as cefazolin is a first-generation cephalosporin with a narrower spectrum than the second-generation cefuroxime.3Neu H.C. Fu K.P. Cefuroxime, a beta-lactamase-resistant cephalosporin with a broad spectrum of gram-positive and negative activity.Antimicrob Agents Chemother. 1978; 13: 657-664Crossref PubMed Scopus (55) Google Scholar We read with great interest the recent editorial by Schein.1Schein O.D. Prevention of endophthalmitis after cataract surgery: making the most of the evidence.Ophthalmology. 2007; 114: 831-832Abstract Full Text Full Text PDF PubMed Scopus (22) Google Scholar We commend the sound analysis of the available evidence regarding the prevention of endophthalmitis and, in particular, appreciate his emphasis on the value of a methodological approach to evaluating research evidence. However, we note that the author erroneously mentioned cefazolin as the intracameral antibiotic used in the European Society of Cataract & Refractive Surgeons randomized control trial of prophylaxis of postoperative endophthalmitis after cataract surgery.2Barry P. Seal D.V. Gettinby G. et al.ESCRS study of prophylaxis of postoperative endophthalmitis after cataract surgery: preliminary report of principal results from a European multicentre study.J Cataract Refract Surg. 2006; 32: 407-410Abstract Full Text Full Text PDF PubMed Scopus (313) Google Scholar Intracameral cefuroxime was the antibiotic employed in the study, and we think this is an important distinction, as cefazolin is a first-generation cephalosporin with a narrower spectrum than the second-generation cefuroxime.3Neu H.C. Fu K.P. Cefuroxime, a beta-lactamase-resistant cephalosporin with a broad spectrum of gram-positive and negative activity.Antimicrob Agents Chemother. 1978; 13: 657-664Crossref PubMed Scopus (55) Google Scholar
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
