Abstract
Objective To compare the effectiveness of topical antibiotic mixtures used in noninstrumental endodontic treatment (NIET) of primary teeth. Methods Electronic databases including MEDLINE, the Cochrane Library, and Scopus database were searched. Randomized clinical trials evaluating the clinical and radiological outcomes of topical antibiotics used in NIET were selected. The revised Cochrane risk-of-bias tool (RoB 2.0) was used to assess the quality of the methodology of the included articles. Results Five articles comparing the outcomes of four different drugs combination were included. Three studies conducted to evaluate the success rate of two combinations of antibacterial drugs consisting of ciprofloxacin-minocycline-metronidazole (3 Mix) in one group and ciprofloxacin-minocycline-ornidazole in the other group showed no statistically significant difference between both groups (P > 0.05). The ciprofloxacin-minocycline-ornidazole group showed better results compared with the 3 Mix group. One study conducted to compare the effectiveness of 3 Mix with ciprofloxacin-tinidazole-minocycline reported no significant difference between both groups, and one study that compared 3 Mix and ciprofloxacin-metronidazole-clindamycin mixture concluded that the overall success rates of both groups were 80.96% and 76.20%, respectively, with no statistically significant difference. Conclusion Based on the overall success rates, the ciprofloxacin-minocycline-ornidazole mixture was considered more effective than the 3 Mix which was more effective than the ciprofloxacin-tinidazole-minocycline and the ciprofloxacin-metronidazole-clindamycin groups. Clinical Relevance. Different antibiotic combinations, showing good clinical and radiographic success in treating necrotic primary teeth, can be used effectively in NIET and this technique can be considered effective for teeth with advanced root resorption and when conventional endodontic treatment is contraindicated.
Highlights
During both chemical and mechanical disinfection, several drugs can be used. It has been reported by Sato et al [2] that disinfection of root canals with various antiseptics and/or antibiotics provides additional disinfection of about 20–40% of conventional root canal debridement. Several drugs such as antibiotics and antiseptics can be International Journal of Dentistry used for debridement, and the selection of those drugs with antibacterial action should be updated to help practitioners choose the best root canal sterilization drugs. us, the antibiotics may be useful in endodontic treatment and root canal sterilization of infected primary teeth and could eliminate all the possible bacteria from lesions [2]
Studies reporting both clinical and radiographical outcomes of topical antibiotics used in noninstrumentation endodontic treatment (NIET) for primary teeth were considered eligible
E studies were selected based on the following inclusion criteria: (i) Randomized clinical trials (RCTs) reporting the clinical and radiographical outcomes of two mixtures of three topical antibiotics, the antibiotic mixture consisting of ciprofloxacin-minocyclinemetronidazole to a modified antibiotic mixture, used in noninstrumentation endodontic treatment” (NIET) conducted in primary teeth with a necrotic pulp of healthy children
Summary
Due to its complex root canal system, root resorption, difficulty in mechanical debridement, and polymicrobial nature of the infection, the successful management of chronically infected primary teeth is a challenge [1], but if the pathological process can be achieved, the preservation of the primary tooth is the best space maintenance for its successor. e liability to reinfection and the difficulties of complete root canal disinfection can make the prognosis less advantageous in chronically infected teeth [2].In an infected root canal, the microbial flora is generally composed of both aerobic and anaerobic bacteria, but it is mainly anaerobic bacteria that most colonize the infected canals [3]. erefore, during root canal debridement, practitioners must clean and disinfect the canals to eradicate these bacteria [2]. Erefore, during root canal debridement, practitioners must clean and disinfect the canals to eradicate these bacteria [2]. During both chemical and mechanical disinfection, several drugs can be used. It has been reported by Sato et al [2] that disinfection of root canals with various antiseptics and/or antibiotics provides additional disinfection of about 20–40% of conventional root canal debridement. Us, the antibiotics may be useful in endodontic treatment and root canal sterilization of infected primary teeth and could eliminate all the possible bacteria from lesions [2]. The presence of minocycline can lead to discoloration; it was necessary to investigate the efficacy of a substitute mixture that is minocycline-free but may be able to produce the same outcomes in comparison with the original mixture [6]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
