Antibiotic Efficacy Assessment of Certain Species of Penicillium fungi

Abstract

This study aimed to evaluate the antimicrobial activity of Penicillium species on soil-isolated gram-positive coccus bacteria. The antimicrobial efficacy of Penicillium species filtrate extracts were determined via disc diffusion and broth dilution assay. A kill curve study was conducted with treated and untreated bacterial populations. There were P. oxalicum, and P. purpurogenum showed the maximum zone in solid surface culture methods, followed by other spices with fewer antibiotic properties. The kill curve study has shown an exposure-dependent inhibition for bacterial populations. With the increase in the exposure periods, microbial growth was significantly reduced. In the broth dilution assay methods, among all treated Penicillium species, only P. oxalicum and P. funiculosum species were shown potent antibiotic properties; other species had given the very least activity. The study interpreted that screening of the suitable strain of microbes for very essentially for industrially important bioactive compounds scale up at industrial set up.