Antibiotic Drug Interaction in Prescribing Asthma Patients in One of the Clinics in the Surabaya Area

Abstract

Drug interactions are interactions that can occur if the effects of a drug are changed by other drugs, food or drinks. The aim of this research is to determine the potential for interactions between antibiotics and other drugs prescribed to asthma patients. Antibiotics are the drugs most widely used for infections caused by bacteria. Determining the mechanism of potential interactions between antibiotics and other drugs prescribed to asthma patients in this study using the Medscape application. The research results showed that there were 2044 prescriptions for the period Juli - December 2022, which provided the highest potential for drug interactions, namely interactions with pharmacokinetic mechanisms in the metabolic phase with 69 incidents (20.47%). Meanwhile, the highest level of severity was monitoring closely, 291 (86.35%) and those with the potential for serious interactions were 46 incidents (13.65%). In this research, the active role of Pharmacy Technicians and Pharmacists is needed to monitor the use of drugs that have the potential to cause drug interactions with prescribing doctors in the hope that undesirable drug interactions can be avoided.