Antibiotic-associated encephalopathy.

Abstract

Bhattacharyya et al. described a type II antibiotic-associated encephalopathy (AAE) where macrolides, among others, were involved.1 The authors suggested that “type 2 AAE closely resemble[d] drug-induced psychotic syndromes caused by perturbations of the D2 dopamine and NMDA glutamate receptors.”1 Where was the evidence of such a mechanism found? Additionally, penetration of clarithromycin into the CSF and brain tissue of a healthy animal is relatively low or absent. It is only when …