Abstract
The dichloromethane extract of Plectranthus ornatus Codd., a tradicional medicinal plant, showed antibiotic activity with minimum inhibitory concentration (MIC) values of 0.4 mg.mL-1 and 100 percent of biofilm inhibition against Staphylococcus aureus strains isolated from animals with mastitis infections. Based on these antibacterial activities, in addition to ethnopharmacological reports from healing men and farmers in Brazil, an herbal soap was produced from this active extract and was tested both in vitro and in vivo. In vivo assays conducted on these herbal soaps led to results similar to those previously conducted with the active extract. These results indicated the great potential of this plant for use as an excipient by preparing herbal antibacterial soaps as an alternative veterinary medicine aimed at controlling bovine mastitis infections on small Brazilian farms.
Highlights
Plectranthus ornatus Codd., is an ornamental and traditional medicinal plant, popularly known in Brazil as “Boldinho” (Lukhoba et al 2006)
According the results observed in the assays, no differences were observed between the two crude extracts of the plant in relation to the antimicrobial activity of the solvent used in this study
By analyzing the minimum inhibitory concentration (MIC) values obtained for the petrol and dichloromethane crude extracts (Table II), it could be concluded that, these values are lower than some values previously found in extract with antimicrobial activity (Duarte et al 2004, Virtuoso et al 2005)
Summary
Plectranthus ornatus Codd. (family Lamiaceae), is an ornamental and traditional medicinal plant, popularly known in Brazil as “Boldinho” (Lukhoba et al 2006). (family Lamiaceae), is an ornamental and traditional medicinal plant, popularly known in Brazil as “Boldinho” (Lukhoba et al 2006). It is African native plant which was brought to the Americas by the Portuguese. P. ornatus leaves have been used by healing men and farmers, in some regions of Brazil, as an antibiotic for the treatment of skin infections (Brasileiro et al 2006, Diaz et al 2010). Some farmers in Brazil have reported the use of this plant to treat bovine mastitis, an inflammation of the mammary gland, which is characterized by physical, chemical, and bacteriological changes in the milk caused by
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